Witryna8 lut 2024 · Imiquimod (IMQ)-induced psoriasis is a widely used preclinical tool for psoriasis research. However, this model is sensitive to the genetic variation of mice. … Witryna1 maj 2009 · Topical application of imiquimod (IMQ), a TLR7/8 ligand and potent immune activator, can induce and exacerbate psoriasis, a chronic inflammatory skin …
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Witryna7 cze 2024 · The IMQ-induced psoriasis-like skin inflammation was induced in Il17rc -deficient ( Il17rc−/−) mice along with age-matched wild-type (WT) and Il17a/f DKO controls. Upon IMQ treatment for 5 days, WT mice developed typical psoriasis-like skin inflammation that was nearly absent in Il17a/f DKO mice ( Fig. 1A ). Witryna5 mar 2024 · experimentation. ApoE mice is considered as successful model for IMQ induced psoriasis-like model, while other hairless mice are not [20]. 2.2 Imiquimod based induced psoriasis-like model . Mice were anesthetized by intra-peritoneal injection with a mixture of ketamin (100mg/kg) and xylazine (7 mg/kg). Then an area … classic cars saskatchewan kijiji
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Witryna12 maj 2015 · Gene expression data from an IMQ induced psoriasis mouse model (GSE27628) and human psoriatic samples (GSE13355) were downloaded from GEO. Both datasets were RMA normalized using GeneSpring and MAS5 data analysis was used to filter out non-expressed probesets (present call in no samples). WitrynaImiquimod-induced psoriasis model This model is usually run in female C57BL/6 mice. Topical application of imiquimod induces cellular infiltration, cytokine responses, epidermal thickening, scaling, and erythema analogous to human plaque-type psoriasis. In C57BL/6 mice, this response includes induction of cytokines IL-17A, IL-23, and IL-22. WitrynaIMQ-induced psoriasis caused by local treatment of 5% IMQ on mouse right ear and back skin was examined. We measured the thickness of the right ear and found that IMQ treatment in the mice resulted in more severe ear swelling than that in … download music to serato