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Metabolism of vinyl chloride

WebR.J. Preston, J.A. Ross, in Comprehensive Toxicology, 2010 1.16.3.5 Halogenated Hydrocarbons. Occupational exposure to vinyl chloride is associated with a high … WebVinyl chloride is thought to depress the CNS via a solvent effect on lipids and protein components of neural membranes that interrupts signal transmission. Reactive metabolic intermediates may also cause specific target organ toxicity by covalently bonding to tissue or initiating destructive chain reactions such as lipid peroxidation.

Metabolism of 14 C-vinyl chloride in vitro and in vivo - PubMed

Web1 okt. 1976 · Vinyl chloride (VCM) is not carcinogenic by itself, it is bioactivated to the highly reactive alkylating oxirane chloroethylene oxide. Further metabolism, apparently, … Web9 feb. 2024 · It is well known that the risk for developing chronic liver injury is influenced by multiple factors, such as genetics, comorbidities, and/or lifestyle choices, such as diet. … exclusive usernames https://dimagomm.com

Vinyl chloride dysregulates metabolic homeostasis and …

WebVinyl Chloride H2C=CHCl or C2H3Cl CID 6338 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, … Webmetabolism of vinyl chloride in mammals and in man, including the formation of monochloroacetic acid and some identified sulfur conjugates is reviewed. Hepatic micro … Web8 mrt. 2016 · Vinyl chloride (VC) is an organochlorine used to create the polymer, polyvinyl chloride. VC is ranked as the 4th most important toxic chemical on the Hazardous … exclusive travel partners reviews

Mutagenicity and metabolism of vinyl chloride and related …

Category:Mutagenicity and Metabolism of Vinyl Chloride and Related …

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Metabolism of vinyl chloride

Metabolism of 14 C-vinyl chloride in vitro and in vivo - PubMed

Web1 nov. 2024 · Vinyl chloride (VC) and 1,4-dioxane (DX) are carcinogens and co-occurring groundwater pollutants. Co-contaminants often affect the ability of microorganisms to … Web18 feb. 2024 · Vinyl chloride is a known human carcinogen associated with highly specific types of cancer like hepatic angiosarcoma (a rare type of liver cancer) and liver problems …

Metabolism of vinyl chloride

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WebLower chlorinated compounds such as cis-dichloroethene (cis-DCE) and vinyl chloride (VC) often accumulate in chloroethene-contaminated aquifers due to incomplete … WebWhen grown on ethane, EA1 cometabolizes vinyl chloride (VC) at a maximum rate of 0.350 micromol/mg volatile suspended solids/d and with a half saturation constant of 0.62 …

WebFirst-order kinetics describes the metabolism of VC up to about 200 mg/m3. The metabolism is believed to proceed through the micro-somal mixed-function oxidase system, forming chloroethylene oxide which rapidly rearranges to chloroacetaldehyde (11). … WebVinyl chloride can exist as liquid under pressure or at low temperatures. It burns easily and is unstable at high temperatures. Vinyl chloride is only slightly soluble in water, but it is …

WebDevelopment and Application of an LC-MS/MS Method for the Detection of the Vinyl Chloride-Induced DNA Adduct N2,3-Ethenoguanine in Tissues of Adult and Weanling … Web24 mrt. 2007 · Vinyl chloride (VC) is a human carcinogen known to undergo metabolism by cytochrome P450 2E1 (CYP2E1) to reactive intermediates that can cause oncogene …

Web• Vinyl chloride can cross the placenta after inhalation exposure in rat dams. • Metabolism in humans and experimental animals occurs via the oxidation of vinyl chloride by CYP …

Web5 apr. 2016 · Vinyl chloride (VC) is a carcinogen generated in groundwater by reductive dechlorination of chloroethenes. Under aerobic conditions, etheneotrophs oxidize … bs shipment\u0027sWebVinyl bromide is metabolized more slowly than vinyl chloride (by about an order of magnitude) (Boltet al.1978), which suggests that vinyl bromide’s greater carcinogenic potency may be related to kinetic differences in metabolism. Vinyl bromide appears to be a more potent inducer of hepatic hemangiosarcoma in rats than is vinyl chloride. bs shin onigashimaWeb1 okt. 1976 · The metabolism of vinyl chloride in mammals and in man, including the formation of monochloroacetic acid and some identified sulfur conjugates is reviewed. … bssh hand registry