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The cystine/glutamate antiporter

WebJul 6, 2024 · Genetic inhibition of mTORC2, or pharmacologic inhibition of the mammalian target of rapamycin (mTOR) kinase, promotes glutamate secretion, cystine uptake, and incorporation into glutathione, linking growth factor receptor signaling with amino acid uptake and utilization. WebOct 1, 2024 · The cystine/glutamate antiporter SLC7A11 (also commonly known as xCT) functions to import cystine for glutathione biosynthesis and antioxidant defense and is overexpressed in multiple human cancers. Recent studies revealed that SLC7A11 overexpression promotes tumor growth partly through suppressing ferroptosis, a form of …

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WebApr 26, 2024 · SLC7A11 encodes the antiporter xCT that imports cystine, the oxidized dimer and main source of intracellular cysteine, and exports glutamate. Targeting xCT induced a … Cystine/glutamate transporter is an antiporter that in humans is encoded by the SLC7A11 gene. The SLC7A11 gene codes for a sodium-independent cystine-glutamate antiporter that is chloride dependent, known as system Xc- or xCT. It regulates synaptic activity by stimulating extrasynaptic receptors … See more SLC7A11 is a member of a heterodimeric Na+-independent anionic amino acid transport system highly specific for cystine and glutamate. This antiporter imports cystine and exports glutamate, which are both … See more Many central nervous system (CNS) disorders are due to a dysfunction in glutamate signaling. Glutamate is transported via … See more There are many mechanisms that exist to regulate the expression of system Xc-, although it is not the sole determinate of extracellular … See more • Bridges CC, Kekuda R, Wang H, Prasad PD, Mehta P, Huang W, Smith SB, Ganapathy V (January 2001). "Structure, function, and regulation of human cystine/glutamate transporter in retinal pigment epithelial cells". Investigative Ophthalmology & … See more newnhambrickwork sky.com https://dimagomm.com

Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient ...

WebJan 2, 2024 · CD44 variant, a cancer stem-like cell marker, stabilizes the xCT antiporter at the cellular membrane, and tumor cells positive for xCT and/or ASCT2 are susceptible to … WebApr 18, 2024 · Here, we report that the cystine/glutamate transporter xCT is essential for RAS-induced tumorigenicity by enhancing antioxidant glutathione synthesis. Our findings … WebxCT, also called SLC7A11, is the light chain component of the cysteine/glutamate amino acid exchange transporter system Xc (1,2). System Xc is composed of two subunits, the light chain (xCT) and the … newnham bookstore

Cystine–glutamate antiporter xCT deficiency suppresses …

Category:The oxidative stress-inducible cystine/glutamate antiporter, …

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The cystine/glutamate antiporter

Iron dyshomeostasis, lipid peroxidation and perturbed expression …

WebFeb 2, 2013 · The antiporter system x c − imports the amino acid cystine, the oxidized form of cysteine, into cells with a 1:1 counter-transport of glutamate. It is composed of a light … WebAug 15, 2024 · DOI: 10.1016/j.aca.2024.05.049 Corpus ID: 220606876; In vivo tracking cystine/glutamate antiporter-mediated cysteine/cystine pool under ferroptosis. …

The cystine/glutamate antiporter

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WebAug 9, 2024 · The cyst (e)ine/glutathione (GSH)/glutathione peroxidase 4 (GPX4) axis is the most frequently targeted pathway to trigger the ferroptosis cascade and suppress tumor growth. Two recent studies... WebJan 7, 2008 · The x cystine/glutamate antiporter is a major plasma membrane transporter for the cellular uptake of cystine in exchange for intracellular glutamate. Its main …

WebThe antiporter system x c– is a sodium independent amino acid transporter that imports extracellular cystine in exchange for exporting intracellular glutamate 1. Given the key … WebMar 16, 2011 · The oxidative stress-inducible cystine/glutamate exchange system, system x − c , transports one molecule of cystine, the oxidized form of cysteine, into cells and thereby releases one molecule of glutamate into the extracellular space.

WebMay 20, 2014 · Exchange of extracellular cystine for intracellular glutamate by the antiporter system x c− is implicated in numerous pathologies. Pharmacological agents that inhibit system x c− activity with high potency have long been sought, but have remained elusive. WebGlutathione peroxidase 4 (GPX4), cystine-glutamate antiporter (system xc-), the sulfur-transfer pathway and a series of genes and regulatory factors related to GSH biosynthesis …

WebJan 8, 2024 · The cystine/glutamate antiporter xCT is a tumor-associated antigen that has been newly identified in many cancer types. By participating in glutathione biosynthesis, xCT protects cancer cells from oxidative stress conditions and ferroptosis, and contributes to metabolic reprogramming, thus promoting tumor progression and chemoresistance.

WebFeb 23, 2024 · SLC7A11/xCT is an antiporter that mediates the uptake of extracellular cystine in exchange for glutamate. Cystine is reduced to cysteine, which is a rate-limiting … newnham bridge tenbury wellsWebFeb 23, 2024 · SLC7A11/xCT is an antiporter that mediates the uptake of extracellular cystine in exchange for glutamate. Cystine is reduced to cysteine, which is a rate-limiting … newnham building chesterfordWebAltogether, these data suggest that cystine/glutamate antiporter function is increased in ischemia, contributing to elevated extracellular glutamate concentration, overactivation of extrasynaptic NMDARs, and ischemic neuronal death. Publication types Research Support, Non-U.S. Gov't MeSH terms Amino Acid Transport System y+ / deficiency newnham bridge